Serres is one of the seven regional districts of the Greek region of Central Macedonia, named after the main town of Serres. Serres includes the municipalities of Amfipoli, Emmanouil Pappas, Iraklia, Nea Zichni, Serres, Sindiki and Visaltia.
In ancient times, the territory of the Serres region belonged to the settlement and dominion of the Thracians. Within the framework of the Greek colonization between the 8th and 6th century BC, settlements were established, which were mainly located on the Aegean coast and served to control the extraction of ore in the Pangeo Mountains and the trade.
With the Roman empire division in 395 AD, the area of Serres fell to the East Roman and Byzantine empires. They kept the exclusive control up to the 6th century.